Sodium borohydride → HCID 11979128, compound

Participants

Reaction Steps

To a solution of (R)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-oxo-pyrrolidine-1-carboxylic acid[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide (example 81.3; 50 mg) in 2 ml of THF was added at 22° C. 12 mg of NaBH4 and stirring was continued for 1.5 h. The mixture was partitioned between 1 N HCl and AcOEt, the organic layer was washed with brine, dried and evaporated to give (3R,4R)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-hydroxy-pyrrolidine-1-carboxylic acid[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide. White solid. MS491.3 ([M+H]+)

Provenance & Evidence