Methanesulfonyl chloride → HCID 58748241, compound

Participants

Reaction Steps

To a solution of (R)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-methylamino-pyrrolidine-1-carboxylic acid[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide (example 83; 26 mg) in 0.8 ml of CH3CN and 22 μl of N,N-diisopropylethylamine was added at 22° C. 6 μl of methanesulfonylchloride and stirring was continued for 3 h. The mixture was diluted with 0.5 ml of MeOH, evaporated and the residue was chromatographed on silica (AcOEt/MeOH, 15:1) to give (R)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-(methanesulfonyl-methyl-amino)-pyrrolidine-1-carboxylic acid[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide. Colorless solid. MS 582.0 ([M+H]+)

Provenance & Evidence