Bromomethylcyclopropane → HCID 86608844, compound

Participants

Reaction Steps

In analogy to example 94.3 5-chloro-thiophene-2-carboxylic acid {(3S,4S)-4-methoxy-1-[(4,5,6,7-tetrahydro-thiazolo[5,4]pyridin-2-ylcarbamoyl)-methyl]-pyrrolidin-3-yl}-amide dihydrochloride (example 94.2) was reacted with 1-(bromomethyl)cyclopropane to give 5-chloro-thiophene-2-carboxylic acid {(3S,4S)-1-[(5-cyclopropylmethyl-4,5,6,7-tetrahydro-thiazolo[5,4]pyridin-2-ylcarbamoyl)-methyl]-4-methoxy-pyrrolidin-3-yl}-amide. Yellow solid. MS 510.5 ([M+H]+)

Provenance & Evidence