Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine → HCID 23397015, compound

HRID 1162726Notes

Reaction equation

HRID 1162726 reaction equation
[C:1]([O:6][CH2:7][CH3:8])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:9]([N:16]([CH2:20][Si](C)(C)C)[CH2:17]OC)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:7]([O:6][C:1]([CH:2]1[CH:3]([CH3:4])[CH2:17][N:16]([CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:20]1)=[O:5])[CH3:8]

Participants

3

Reactant 2

HCID 353442Benzyl(methoxymethyl)((trimethylsilyl)methyl)amineHCID 429065Ethyl trans-crotonate

Product 1

HCID 23397015HCID 23397015, compound

Procedure

102.1 In analogy to example 101.1 ethyl crotonate and N-benzyl-N-(methoxymethyl)tri-methylsilylmethylamine (CAS 93102-05-7) were reacted to give (3RS,4RS)-1-benzyl-4-methyl-pyrrolidine-3-carboxylic acid ethyl ester. Light yellow solid. MS 248.3 ([M+H]+)

Sources & evidence

ORD record
ord-318f96f41a3143b5b245e1899a539c9a
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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