Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine → HCID 57304770, compound

HRID 1162728Notes

Reaction equation

HRID 1162728 reaction equation
[CH2:1]([O:3][C:4](=[O:10])/[CH:5]=[CH:6]/[CH:7]([CH3:9])[CH3:8])[CH3:2].[CH2:11]([N:18]([CH2:22][Si](C)(C)C)[CH2:19]OC)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:1]([O:3][C:4]([CH:5]1[CH:6]([CH:7]([CH3:9])[CH3:8])[CH2:22][N:18]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:19]1)=[O:10])[CH3:2]

Participants

3

Reactant 2

HCID 353442Benzyl(methoxymethyl)((trimethylsilyl)methyl)amineHCID 5315066Ethyl (2E)-4-methyl-2-pentenoate

Product 1

HCID 57304770HCID 57304770, compound

Procedure

104.1 In analogy to example 101.1 (E)-4-methyl-pent-2-enoic acid ethyl ester and N-benzyl-N-(methoxymethyl)tri-methylsilylmethylamine (CAS 93102-05-7) were reacted to give (3RS,4RS)-1-benzyl-4-isopropyl-pyrrolidine-3-carboxylic acid ethyl ester. Light yellow oil.

Sources & evidence

ORD record
ord-add019c127dd4fc3b2fca08d042cbb5d
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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