Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine → HCID 68646973, compound

HRID 1162729Notes

Reaction equation

HRID 1162729 reaction equation
[CH3:1][O:2][C:3](=[O:16])/[CH:4]=[CH:5]/[CH2:6][CH2:7][O:8][Si:9]([C:12]([CH3:15])([CH3:14])[CH3:13])([CH3:11])[CH3:10].[CH2:17]([N:24]([CH2:28][Si](C)(C)C)[CH2:25]OC)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:1][O:2][C:3]([CH:4]1[CH:5]([CH2:6][CH2:7][O:8][Si:9]([C:12]([CH3:13])([CH3:15])[CH3:14])([CH3:10])[CH3:11])[CH2:28][N:24]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:25]1)=[O:16]

Participants

3

Reactant 2

HCID 353442Benzyl(methoxymethyl)((trimethylsilyl)methyl)amineHCID 11630130HCID 11630130, compound

Product 1

HCID 68646973HCID 68646973, compound

Procedure

105.1 In analogy to example 101.1 ((E)-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid methyl ester (CAS 688801-64-1) and N-benzyl-N-(methoxymethyl)tri-methylsilylmethylamine (CAS 93102-05-7) were reacted to give (3RS,4RS)-1-benzyl-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-pyrrolidine-3-carboxylic acid methyl ester. Light yellow oil. MS 378.3 ([M+H]+)

Sources & evidence

ORD record
ord-8026196885c443a4821e7a16b6e1fca3
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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