Cyanoacetamide → 2-Aminothiophene-3-carboxamide

Participants

Reaction Steps

A solution of 2,5-dihydroxy-1,4-dithiane (5.83 g, 38.3 mmol), 2-cyanoacetamide (8.4 g, 99.1 mmol) and triethylamine (10 mL, 71.9 mmol) in EtOH (30 mL) was heated at 70° C. for 2 h then allowed to stand overnight. The reaction mixture was reduced by half in vacuo and the solution cooled with ice to produce a precipitate. The solid was filtered off, washing with heptane (200 mL) to give product as a brown solid (7.12 g, 50.1 mmol, 51

Provenance & Evidence