Hydrazinium chloride → HCID 178506290, compound

HRID 1162788Notes

Reaction equation

HRID 1162788 reaction equation
C[N:2](C)[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9](=O)[C:10]([F:13])([F:12])[F:11].Cl.[NH2:17]N.CO.C(Cl)Cl>C(O)CCC>[F:11][C:10]([F:13])([F:12])[C:9]1[C:4]2[CH:5]=[N:6][CH:7]=[CH:8][C:3]=2[NH:2][N:17]=1

Participants

5

Reactant 3

HCID 115031Hydrazinium chlorideHCID 10608834HCID 10608834, compoundHCID 21226129Dichloromethane methanol

Product 1

HCID 178506290HCID 178506290, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
200 °C

Procedure

A suspension of 1-(4-(dimethylamino)pyridin-3-yl)-2,2,2-trifluoroethanone (259 mg, 1.187 mmol) and hydrazine monohydrochloride (244 mg, 3.56 mmol) in butan-1-ol (2.5 mL) was heated to 200° C. for 35 min. The reaction mixture was applied to a 10 g SPE cartridge that had been pre-conditioned with 3% MeOH/DCM and eluted with the same system to give a light yellow solid (189 mg, 1.0 mmol, 85%).

Workup

  1. washeluted with the same system

Sources & evidence

ORD record
ord-a127394b90a147f292daeb299b021ef7
Source dataset
uspto-grants-2010_10
Patent number
US07820707B2

Reaction notes

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