反应详情

To a solution of 1-(4-fluorobenzyl)-4-(1H-imidazol-1-ylcarbonyl)piperazin-2-one (2.49 g, 8.2 mmol) in 20 mL of anhydrous MeCN, under an atmosphere of nitrogen, was added iodomethane (2.05 mL, 32.9 mmol). The reaction was covered in aluminum foil and stirred at room temperature overnight. The reaction was concentrated under vacuum, co-evaporated with toluene under vacuum, followed by drying under high vacuum to provide the title compound. 1H NMR (400 MHz, DMSO-d6) δ 9.59 (s, 1H), 8.02 (s, 1H), 7.84 (s, 1H), 7.36 (dd, J=8.4, 5.7 Hz, 2H), 7.19 (t, J=8.7 Hz, 2H), 4.56 (s, 2H), 4.23 (s, 2H), 3.91 (s, 3H), 3.77 (bs, 2H), 3.40 (t, J=5.2 Hz, 2H). ES MS (M)=317.

1. concentrationThe reaction was concentrated under vacuum, co-evaporated with toluene under vacuum
2. customby drying under high vacuum