4-Formylbenzoic acid → 4-(2-Ethoxycarbonyl-4-methyl-3-oxo-pent-1-enyl)benzoic acid

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Reaction Steps

29.0 g of ethyl isobutyrylacetate and 33.0 g of 4-carboxybenzaldehyde are heated with a water trap for 6 h. The reaction solution is concentrated, taken up in ethyl acetate and extracted with 20% strength ammonium chloride solution and saturated sodium chloride solution. The organic phase is dried over magnesium sulfate, concentrated and directly reacted further to 45. 50.0 g of an oil are obtained. C16H18O5 (290.3): MS (ESI+): 291.1 (M+H)+, tR=1.42 min (Gradient 2).

Provenance & Evidence