HCID 11853424, compound → HCID 54686990, compound

Participants

Reaction Steps

A mixture of the 7-(4-benzyloxy-2-oxo-2,5-dihydropyrrol-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one (8 mg, 0.017 mmol) prepared in Example 1-8 and palladium hydroxide (2 mg) was dissolved in methanol. The obtained mixture was stirred in a hydrogen atmosphere for 1 hour. Thereafter, the reaction solution was filtered through celite, and the concentrated residue was then preparatively separated by preparative HPLC (column: Combi ODS (φ: 28.0 mm×50 mm), manufactured by Wako; developing solvent: 0.05% trifluoroacetic acid-containing water: 0.05% trifluoroacetic acid-containing acetonitrile=90:10 to 5:95), so as to obtain 7-(4-hydroxy-2-oxo-2,5-dihydropyrrol-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one (1 mg, 15%) in the form of a colorless oil substance.

Provenance & Evidence