Pentaethylene glycol monomethyl ether → 2,5,8,11,14,17-Hexaoxanonadecan-19-oic acid
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][C:19]([OH:21])=[O:20].O[CH2:23][C@H:24]1[O:28][C:27](=O)[N:26]([C:30]2[CH:39]=[C:38]3[C:33]([CH:34]=[C:35]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=4[C:47]([F:50])([F:49])[F:48])[NH:36][C:37]3=[O:40])=[CH:32][CH:31]=2)[CH2:25]1.C[O:52]CCOCCOCCOCCOCCO>>[O:52]=[C:18]([O:17][CH2:16][CH:15]([CH2:23][C@@H:24]1[O:28][CH2:27][N:26]([C:30]2[CH:39]=[C:38]3[C:33]([CH:34]=[C:35]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=4[C:47]([F:48])([F:50])[F:49])[NH:36][C:37]3=[O:40])=[CH:32][CH:31]=2)[CH2:25]1)[O:14][CH2:13][CH2:12][O:11][CH2:10][CH2:9][O:8][CH2:7][CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[C:19]([O-:21])=[O:20].[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][C:19]([OH:21])=[O:20]Participants
5
Reactant 3
Product 2
Procedure
The title compound was synthesized by a condensation method similar to that of Step A of Example 3-1 using [2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid instead of Boc-Sar-OH and 7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-13 instead of 7-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-14. However, [2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid was synthesized by a method similar to that of Step A of Example 4-39 using pentaethylene glycol monomethyl ether instead of pentaethylene glycol monobenzyl ether.
Sources & evidence
- ORD record
- ord-606a7296473240a6a86f64a69360917f
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07820693B2
Reaction notes
Loading…