HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,6,9,12,15-Pentaoxahexadecanoic acid → 3,6,9,12,15-Pentaoxahexadecanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,6,9,12,15-Pentaoxahexadecanoic acid | HCID 85242 | — |
| Reactant | Tetraethylene glycol monomethyl ether | HCID 90263 | — |
| Reactant | 7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one | HCID 11853672 | — |
| Product | 3,6,9,12,15-Pentaoxahexadecanoic acid | HCID 85242 | — |
| Product | (S)-2-Oxo-3-[1-oxo-3-(2-trifluoromethylphenyl)-1,2-dihydroisoquinolin-7-yl]oxazolidin-5-ylmethyl(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetate | HCID 86761202 | — |
Reaction Steps
The title compound was synthesized by a condensation method similar to that of Step A of Example 3-1 using (2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetic acid instead of Boc-Sar-OH and 7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-13 instead of 7-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-14. However, (2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetic acid was synthesized by a method similar to that of Step A of Example 4-39 using tetraethylene glycol monomethyl ether instead of pentaethylene glycol monobenzyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820693B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-89c96f8092a34337a394147ebbee8172 |
| Source note | uspto-grants-2010_10 |