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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1162951Generated: October 30, 2026

3,6,9,12,15-Pentaoxahexadecanoic acid → 3,6,9,12,15-Pentaoxahexadecanoic acid

https://huagongshe.com/reaction/1162951

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,6,9,12,15-Pentaoxahexadecanoic acidHCID 85242—
ReactantTetraethylene glycol monomethyl etherHCID 90263—
Reactant7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-oneHCID 11853672—
Product3,6,9,12,15-Pentaoxahexadecanoic acidHCID 85242—
Product(S)-2-Oxo-3-[1-oxo-3-(2-trifluoromethylphenyl)-1,2-dihydroisoquinolin-7-yl]oxazolidin-5-ylmethyl(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetateHCID 86761202—

Reaction Steps

The title compound was synthesized by a condensation method similar to that of Step A of Example 3-1 using (2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetic acid instead of Boc-Sar-OH and 7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-13 instead of 7-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-14. However, (2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)acetic acid was synthesized by a method similar to that of Step A of Example 4-39 using tetraethylene glycol monomethyl ether instead of pentaethylene glycol monobenzyl ether.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07820693B2
Source datasetuspto-grants-2010_10
ORD IDord-89c96f8092a34337a394147ebbee8172
Source noteuspto-grants-2010_10