Sodium hydride → HCID 57558159, compound

Participants

Reaction Steps

Sodium hydride (133 mg, 3.32 mmol) was added to 5 mL of a solution of cis-1,3-O-benzylideneglycerol (300 mg, 1.66 mmol) in DMF, and the mixture was stirred at room temperature for two hours. (2-bromoethoxy)-tert-butyldimethylsilane (534 μl, 3.32 mmol) was added to the mixture which was then stirred at room temperature for two hours. Aqueous saturated ammonium chloride was added to the mixture, followed by extraction with ethyl acetate. The extract was washed with saturated saline and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain a crude product, tert-butyldimethyl-[2-(2-phenyl-[1,3]dioxan-5-yloxy)ethoxy]silane (343 mg) as a colorless oil.

Provenance & Evidence