Ammonium Chloride → HCID 15047376, compound

Participants

Reaction Steps

A solution of TBAF in 1 M-THF (1 mL, 1.00 mmol) was added to 5 mL of a solution of crude tert-butyldimethyl-[2-(2-phenyl-[1,3]dioxan-5-yloxy)ethoxy]silane (343 mg, 1.01 mmol) obtained in Step A in THF, and the mixture was stirred at room temperature for 16 hours. Aqueous saturated ammonium chloride was added to the mixture, followed by extraction with ethyl acetate. The extract was washed with saturated saline and then dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (methylene chloride:methanol=50:1) to obtain 2-(2-phenyl-[1,3]dioxan-5-yloxy)ethanol (39 mg, yield: 17%) as a colorless oil.

Provenance & Evidence