Ammonia → HCID 178513828, compound

HRID 1162997Notes

Reaction equation

HRID 1162997 reaction equation
C([O:3][C:4]([C:6]1[N:15]=[C:14]([OH:16])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=2)[N:7]=1)=O)C.[NH3:18]>CO>[OH:16][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=2)[N:7]=[C:6]([C:4]([NH2:18])=[O:3])[N:15]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178470314ethyl 6-hydroxy-4-oxo-1H-quinazoline-2-carboxylate

Product 1

HCID 178513828HCID 178513828, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4,6-Dihydroxy-quinazoline-2-carboxylic acid ethyl ester (11 mmol) is dissolved in methanol (50 ml) containing ammonia (4N). The mixture is stirred for 3 hours and the solid material formed is filtered off. A pale powder with mp. 305° C. (decomposition) is obtained.

Workup

  1. customthe solid material formed
  2. filtrationis filtered off
  3. customA pale powder with mp. 305° C. (decomposition) is obtained

Sources & evidence

ORD record
ord-f8b6429a65b846da9e49c2a98dd8ef29
Source dataset
uspto-grants-2010_10
Patent number
US07820818B2

Reaction notes

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