HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 24887569, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycidol | HCID 11164 | — |
| Reactant | 2-{4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propan-2-ol | HCID 22337996 | — |
| Product | HCID 24887569 | HCID 24887569 | 48% |
Reaction Steps
A mixture of Example 1 (45 mg, 0.14 mmol), S-(−) glycidol (330 mg, 4.2 mmol) and triethylamine (5 μL) in ethanol (15 mL) was heated at 75° C. for 2 h. The reaction was concentrated in vacuo. The crude material was purified by chromatography on silica gel eluting with 100% ethyl acetate to provide the title compound (26 mg, 48% yield) as a white solid. MS: (M+H)+=387.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820814B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-1ac8b563d8074582aa8d9458b5514389 |
| Source note | uspto-grants-2010_10 |