HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 20767704, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | 2-{4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propan-2-ol | HCID 22337996 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 20767704 | HCID 20767704 | 43.9% |
Reaction Steps
A mixture of Example 1 (50 mg, 0.16 mmol), 3-bromo-1-propanol (100 μL, 1.1 mmol) and potassium carbonate (100 mg, 0.72 mmol) in acetonitrile (1.5 mL) was stirred overnight at 35° C. The mixture was filtered, concentrated and purified by chromatography on silica gel eluting with 30% ethyl acetate in dichloromethane to provide the title compound (26 mg, 39% yield) as a light beige solid. MS: (M+H)+=371
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820814B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-25be05be8667496184f6710bb3be944b |
| Source note | uspto-grants-2010_10 |