Methanesulfonamide → HCID 178431435, compound

HRID 1163069Notes

Reaction equation

HRID 1163069 reaction equation
[CH3:1][C:2]1[C:3]([O:18][CH2:19][CH2:20][CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])=[CH:4][N:5]2[C:10]=1[C:9]([O:11]C1C=CC=CC=1)=[N:8][CH:7]=[N:6]2.CS(N)(=O)=O>>[OH:11][C:9]1[C:10]2=[C:2]([CH3:1])[C:3]([O:18][CH2:19][CH2:20][CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])=[CH:4][N:5]2[N:6]=[CH:7][N:8]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 22508873N-[3-(5-methyl-4-phenoxy-pyrrolo[2,1-f][1,2,4]triazin-6-yloxy)-propyl]-methanesulfonamide

Product 1

HCID 178431435HCID 178431435, compoundYield 64%

Procedure

The compound from Step A above was treated with methanesulfonamide by a procedure similar to that described for the preparation of Example 24 to obtain N-[3-(4-hydroxy-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)-propyl]-methanesulfonamide. (64% yield). MS: (M+H)+=301.

Workup

  1. customthat described for the preparation of Example 24

Sources & evidence

ORD record
ord-bb834817a87a46bab0067bb0bf82c9ba
Source dataset
uspto-grants-2010_10
Patent number
US07820814B2

Reaction notes

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