Triethylamine → HCID 58970771, compound

Participants

Reaction Steps

A solution of 1-{4-[(2-phenyl-1H-benzimidazol-1-yl)methyl]benzoyl}pyrrolidin-3-ol (0.85 g, 3 mmol) in DCM at 0° C. is treated with and triethylamine (0.91 mL, 6.6 mmol) followed by methylsulfonyl chloride (0.25 mL, 3.3 mmol), stirred at room temperature overnight and concentrated to give methanesulfonic acid 1-[4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoyl]-pyrrolidin-3-yl ester as a white powder (1.4 g) identified by HPLC and MS [476.3 m/e (M+H)].

Provenance & Evidence