Dimethylformamide → HCID 46231335, compound

Participants

Reaction Steps

A solution of methanesulfonic acid 1-[4-(2-phenyl-benzoimidazol-1-ylmethyl)-benzoyl]-pyrrolidin-3-yl ester (71 mg, 0.15 mmol) in DMF is treated with N-ethylmethylamine (0.038 mL, 0.45 mmol), stirred at room temperature overnight and concentrated in vacuo. The resultant residue is dissolved in a mixture of DMSO, MeOH and water (1.5 mL) and purified by reverse-phase semi-preparative HPLC1 to give the title product as a white powder (6.4 mg), identified by HPLC2 and MS [439.6 m/e (M+H)], retention time 1.48 min.

Provenance & Evidence