HCID 23111659, compound → HCID 23111808, compound

HRID 1163281Notes

Reaction equation

HRID 1163281 reaction equation
C([O:8][C:9]1[CH:24]=[CH:23][C:12]2[CH:13]=[C:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:15][CH2:16][O:17][C:11]=2[CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:24]=[CH:23][C:12]2[CH2:13][CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:15][CH2:16][O:17][C:11]=2[CH:10]=1

Participants

4

Reactant 1

HCID 23111659HCID 23111659, compound

Product 1

HCID 23111808HCID 23111808, compoundYield 105.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 8-(benzyloxy)-2,3-dihydro-1-benzoxepine-4-carboxylate (3.5 g) was dissolved in ethanol (50 mL), and the solution was subjected to catalytic reduction using 10% palladium on carbon (0.35 g) for 3 days. The catalyst was filtered off, and the solvent of the filtrate was evaporated. The residue was purified by silica gel column chromatography (ethyl acetate:hexane) to give the title compound (2.7 g) as an oil.

Workup

  1. customfor 3 days
  2. filtrationThe catalyst was filtered off
  3. customthe solvent of the filtrate was evaporated
  4. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane)

Sources & evidence

ORD record
ord-a643ea724c48412f99322ab4345ce18b
Source dataset
uspto-grants-2010_10
Patent number
US07820837B2

Reaction notes

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