反应详情

A mixture of 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (10.9 g, 51.8 mmol) and 1 M aqueous sodium hydroxide solution (500 mL) was heated under reflux for 2 hr. The reaction mixture was allowed to cool, acidified with conc. sulfuric acid and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (6-hydroxy-1-benzofuran-3-yl)acetic acid (8.27 g, 83%) as brown crystals.

1. temperaturewas heated
2. temperatureunder reflux for 2 hr
3. temperatureto cool
4. extractionextracted with ethyl acetate
5. washThe extract was washed with saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure