Water → HCID 23111827, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4′-hydroxy-2′,6′-dimethyl-3-biphenylcarbaldehyde (2.26 g, 10.0 mmol) and benzyl bromide (3.42 g, 20.0 mmol) in N,N-dimethylformamide. (10 mL) was added potassium carbonate (2.76 g, 20.0 mmol), and the mixture was stirred at 70° C. for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-10% ethyl acetate/hexane) to give the title compound (2.90 g, yield 92%) as a colorless oil.

Provenance & Evidence