Citric Acid → HCID 23111674, compound

Participants

Reaction Steps

To a solution of ethyl (6-((3-phenoxybenzyl)oxy)-1,2,3,4-tetrahydro-1-naphthalenyl)acetate (0.481 g, 1.15 mmol) in a mixed solvent of ethanol (4 mL) and tetrahydrofuran (4 mL) was added 2 M aqueous sodium hydroxide solution (2 mL), and the mixture was stirred at room temperature for 9 hr. Water was added to the reaction mixture, and the mixture was neutralized with 10% aqueous citric acid solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the title compound (0.360 g, yield 81%) as colorless needle crystals.

Provenance & Evidence