Sodium Hydroxide → HCID 86761203, compound

Participants

Reaction Steps

To a solution of {6-[(4-{[(2-phenylethyl)(4-phenyl-1,3-thiazol-2-yl)amino]methyl}benzyl)oxy]-2,3-dihydro-1-benzofuran-3-yl}acetic acid (0.541 g, 0.938 mmol) in methanol (5 mL) was added 2 M aqueous sodium hydroxide solution (1 mL), and the mixture was concentrated under reduced pressure. Water (50 mL) and methanol (20 mL) were added to the obtained residue, and a solution of calcium chloride (0.111 g, 1.00 mmol) in water (5 mL) was added thereto. The mixture was concentrated under reduced pressure, and the precipitated solid was collected by filtration and washed with water to give the title compound (0.454 g, yield 81%) as a pale-yellow amorphous solid.

Provenance & Evidence