HCID 67274191, compound → HCID 67273734, compound

HRID 1163348Notes

Reaction equation

HRID 1163348 reaction equation
C(OC([N:11]1[CH2:14][CH:13]([N:15]([C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH2:36][C@H:35]([CH2:37][NH:38][C:39](=[O:41])[CH3:40])[O:34][C:33]3=[O:42])=[CH:28][C:27]=2[F:43])C(OCC2C=CC=CC=2)=O)[CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH:11]1[CH2:14][CH:13]([NH:15][C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH2:36][C@H:35]([CH2:37][NH:38][C:39](=[O:41])[CH3:40])[O:34][C:33]3=[O:42])=[CH:28][C:27]=2[F:43])[CH2:12]1

Participants

4

Reactant 1

HCID 67274191HCID 67274191, compound

Product 1

HCID 67273734HCID 67273734, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1.11 g of 3-({4-[(5S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-benzyloxycarbonyl-amino)-azetidine-1-carboxylic acid benzyl ester (1.88 mmol) and 200 mg Pd/c 10% in methanol was stirred under hydrogen for 5 h. The Pd/C was filtered and the filtrate evaporated to dryness.

Workup

  1. filtrationThe Pd/C was filtered
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-7fd9858a8d2b4d1c8c1fd190128d5d74
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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