7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → HCID 67274644, compound

HRID 1163353Notes

Reaction equation

HRID 1163353 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:19]2[CH2:23][C@H:22]([CH2:24][NH:25][C:26](=[O:28])[CH3:27])[O:21][C:20]2=[O:29])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C@@H:14]2[CH2:18][CH2:17][NH:16][CH2:15]2)[CH2:10][CH2:9]1.Cl[C:31]1[N:40]=[C:39]2[C:34]([C:35](=[O:47])[C:36]([C:44]([OH:46])=[O:45])=[CH:37][N:38]2[CH:41]2[CH2:43][CH2:42]2)=[CH:33][C:32]=1[F:48]>>[C:26]([NH:25][CH2:24][C@@H:22]1[O:21][C:20](=[O:29])[N:19]([C:4]2[CH:5]=[CH:6][C:7]([N:8]3[CH2:13][CH2:12][N:11]([C@@H:14]4[CH2:18][CH2:17][N:16]([C:31]5[N:40]=[C:39]6[C:34]([C:35](=[O:47])[C:36]([C:44]([OH:46])=[O:45])=[CH:37][N:38]6[CH:41]6[CH2:43][CH2:42]6)=[CH:33][C:32]=5[F:48])[CH2:15]4)[CH2:10][CH2:9]3)=[C:2]([F:1])[CH:3]=2)[CH2:23]1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 110551427-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidHCID 67273748HCID 67273748, compound

Product 1

HCID 67274644HCID 67274644, compound

Procedure

This compound was synthesized in analogy to the procedure described in Example 19 using 0.0 90 g N-{(5S)-3-[3-fluoro-4-(4-{(3R)-pyrrolidin-3-yl}-piperazin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.22 mmol) and 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-[1,8]naphthyridine-3-carboxylic acid (0.22 mmol).

Workup

  1. customThis compound was synthesized in analogy to the procedure

Sources & evidence

ORD record
ord-de02aba2df4140f697528522c8a88bf4
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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