7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → HCID 10121818, compound

HRID 1163354Notes

Reaction equation

HRID 1163354 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:14]2[CH2:18][C@H:17]([CH2:19][NH:20][S:21]([CH3:24])(=[O:23])=[O:22])[O:16][C:15]2=[O:25])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Cl[C:27]1[N:36]=[C:35]2[C:30]([C:31](=[O:43])[C:32]([C:40]([OH:42])=[O:41])=[CH:33][N:34]2[CH:37]2[CH2:39][CH2:38]2)=[CH:29][C:28]=1[F:44]>>[CH:37]1([N:34]2[C:35]3[C:30](=[CH:29][C:28]([F:44])=[C:27]([N:11]4[CH2:12][CH2:13][N:8]([C:7]5[CH:6]=[CH:5][C:4]([N:14]6[CH2:18][C@H:17]([CH2:19][NH:20][S:21]([CH3:24])(=[O:22])=[O:23])[O:16][C:15]6=[O:25])=[CH:3][C:2]=5[F:1])[CH2:9][CH2:10]4)[N:36]=3)[C:31](=[O:43])[C:32]([C:40]([OH:42])=[O:41])=[CH:33]2)[CH2:38][CH2:39]1

Participants

3

Reactant 2

HCID 110551427-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidHCID 67273933HCID 67273933, compound

Product 1

HCID 10121818HCID 10121818, compound

Procedure

This compound was synthesized in analogy to the procedure described in Example 10 using 0.082 g N-[(5R)-3-(3-fluoro-4-piperazin-1-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-methansulfonamide (0.22 mmol) and 0.067 g 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-[1,8]naphthyridine-3-carboxylic acid (0.22 mmol).

Workup

  1. customThis compound was synthesized in analogy to the procedure

Sources & evidence

ORD record
ord-d65f3d4765c349c998497f7fa8805ddf
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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