HCID 67273776, compound → HCID 67273834, compound

HRID 1163358Notes

Reaction equation

HRID 1163358 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:28][C@H:27]([CH2:29][NH:30][C:31](=[O:33])[CH3:32])[O:26][C:25]3=[O:34])=[CH:20][C:19]=2[F:35])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O.[Pd]>[F:35][C:19]1[CH:20]=[C:21]([N:24]2[CH2:28][C@H:27]([CH2:29][NH:30][C:31](=[O:33])[CH3:32])[O:26][C:25]2=[O:34])[CH:22]=[CH:23][C:18]=1[NH:17][CH:14]1[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]1

Participants

4

Reactant 1

HCID 67273776HCID 67273776, compound

Product 1

HCID 67273834HCID 67273834, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A suspension of 480 mg (1 mmol) 4-{4-[(5S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenylamino}-piperidine-1-carboxylic acid benzyl ester and Pd/C in 2 ml of a methanol/acetic acid 1/1 mixture was stirred under H2 for 4 h. The Pd/C was filtered and the filtrate was evaporated to dryness.

Workup

  1. filtrationThe Pd/C was filtered
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-c1f414fea360487b8f67a22bc9cad70b
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

Loading…