Methanol → HCID 86597768, compound

HRID 1163360Notes

Reaction equation

HRID 1163360 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@@H:23]([CH:25](C)[NH:26][C:27]([SH:29])=[S:28])[O:22][C:21]3=[O:31])=[CH:16][C:15]=2[F:32])[CH2:10][CH2:9]1)=O)(C)(C)C.[CH3:33]O>>[CH3:33][S:29][C:27](=[S:28])[NH:26][CH2:25][C@@H:23]1[O:22][C:21](=[O:31])[N:20]([C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[C:15]([F:32])[CH:16]=2)[CH2:24]1

Participants

3

Reactant 2

HCID 887MethanolHCID 86597769HCID 86597769, compound

Product 1

HCID 86597768HCID 86597768, compound

Procedure

A suspension of 510 mg 4-{2-fluoro-4-[(5S)-5-(methyl-sulfanylthiocarbonylamino-methyl)2-oxo-oxazolidin-3-yl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (1.05 mmol) in 1.25 M/methanol was stirred for 5 days. The solvent was evaporated and the residue digested in water. The water layer was neutralized at pH 7 with a saturated solution of sodium bicarbonate and evaporated to dryness. The residue was digested in CH2Cl2/MeOH. The salts were filtered and the solvent evaporated:

Workup

  1. customThe solvent was evaporated
  2. customevaporated to dryness
  3. filtrationThe salts were filtered
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-15c7f71a822046708f63ca85f4389b8f
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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