HCID 68421632, compound → tert-Butyl 4-sulfanylpiperidine-1-carboxylate

HRID 1163364Notes

Reaction equation

HRID 1163364 reaction equation
[C:1]([O-:4])(=[O:3])C.C([O-])(=O)C.[B+3].ClC1C=[C:19]2[C:14]([C:15](=O)C(C([O-])=O)=CN2C2CC2)=[CH:13]C=1F.FC1C=C(N2C[C@H](CNC(=O)C)OC2=O)C=CC=1[S:36][CH:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>>[C:14]([O:4][C:1]([N:40]1[CH2:39][CH2:38][CH:37]([SH:36])[CH2:42][CH2:41]1)=[O:3])([CH3:19])([CH3:15])[CH3:13]

Participants

3

Reactant 2

HCID 68421632HCID 68421632, compoundHCID 178476581HCID 178476581, compound

Product 1

HCID 21906090tert-Butyl 4-sulfanylpiperidine-1-carboxylate

Procedure

Was prepared in analogy to example 28 starting from 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate boron diacetate and (S)—N-[[3-(3-fluoro-4-(4-piperidinylsulfanyl)-phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide. The later being obtained from 4-mercapto-piperidine-1-carboxylic acid tert-butyl ester (J. Antibiotics, 1995, 48, 408-16).

Sources & evidence

ORD record
ord-52d3cc96727e485aa05fd6ce47a9135f
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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