3,5-Diamino-2-methylbenzoic acid → HCID 178497378, compound

HRID 1163368Notes

Reaction equation

HRID 1163368 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[C:11]=S)([CH3:3])[CH3:2].[NH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=1[NH2:24])[C:17]([O:19][CH3:20])=[O:18]>>[CH3:20][O:19][C:17]([C:16]1[CH:21]=[CH:22][C:23]2[NH:24][C:11]([NH:10][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[CH:1]([CH3:3])[CH3:2])=[N:13][C:14]=2[CH:15]=1)=[O:18]

Participants

3

Reactant 2

HCID 1355243,5-Diamino-2-methylbenzoic acidHCID 1420522-Isopropylphenyl isothiocyanate

Product 1

HCID 178497378HCID 178497378, compound

Procedure

1-Isopropyl-2-isothiocyanatobenzene (5 mmol) and methyl 3,4-diaminobenzoate (5 mmol) were reacted, following general procedure B, to yield 2-(2-Isopropylphenylamino)-1H-benzimidazole-5-carboxylic acid methyl ester, which was purified by silica gel chromatography using DCM/ethyl acetate as eluent.

Sources & evidence

ORD record
ord-34513f43a8a94b4ba9b51affbb539a08
Source dataset
uspto-grants-2010_10
Patent number
US07820821B2

Reaction notes

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