Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 59522577, compound

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Reaction Steps

The ester obtained as above was hydrolyzed using general procedure C to yield 2-(2-isopropylphenylamino)-1H-benzimidazole-5-carboxylic acid. The carboxylic acid (0.25 mmol) was coupled with 3-(2-morpholin-4-yl-ethylamino)-1H-indazol-6-ylamine (0.25 mmol) using HBTU employing general procedure D. The product, 2-(2-Isopropylphenylamino)-3H-benzimidazole-5-carboxylic acid [3-(2-morpholin-4-yl-ethylamino)-1H-indazol-6-yl]-amide, was obtained after purification by silica gel chromatography using DCM/methanol as eluent. MS: m/z 539 (M+H)+.

Provenance & Evidence