3,5-Diamino-2-methylbenzoic acid → HCID 68445131, compound

HRID 1163380Notes

Reaction equation

HRID 1163380 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[C:10]=S)[CH3:2].[NH2:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][C:22]=1[NH2:23])[C:16]([O:18][CH3:19])=[O:17]>>[CH3:19][O:18][C:16]([C:15]1[CH:20]=[CH:21][C:22]2[N:23]=[C:10]([NH:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[CH2:1][CH3:2])[NH:12][C:13]=2[CH:14]=1)=[O:17]

Participants

3

Reactant 2

HCID 1355243,5-Diamino-2-methylbenzoic acidHCID 27962132-Ethylphenyl isothiocyanate

Product 1

HCID 68445131HCID 68445131, compound

Procedure

2-Ethyl-1-isothiocyanatobenzene (3 mmol) and methyl 3,4-diaminobenzoate (3 mmol) were reacted, following general procedure B, to yield 2-(2-ethylphenylamino)-3H-benzimidazole-5-carboxylic acid methyl ester, which was purified by silica gel chromatography using DCM/ethyl acetate as eluent.

Sources & evidence

ORD record
ord-52901b8ee089466598c86ccb14ee7a8b
Source dataset
uspto-grants-2010_10
Patent number
US07820821B2

Reaction notes

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