1,2-Dichloroethane → HCID 178426307, compound

Participants

Reaction Steps

A solution of {1-[4,5-diamino-2-(1H-indazol-6-ylcarbamoyl)-phenyl]-piperidin-4-yl}-carbamic acid tert-butyl ester (0.3 mmol; see Example 155) in DMF (1 mL) was reacted with 1-isothiocyanato-2-trifluoromethylbenzene (0.3 mmol) followed by cyclization in situ using EDC as described in general procedure B to provide {{1-[6-(1H-Indazol-6-ylcarbamoyl)-2-(3-methylpyridin-2-ylamino)-3H-benzoimidazol-5-yl]-piperidin-4-yl}-carbamic acid tert-butyl ester. MS: m/z 582 (M+H)+.

Provenance & Evidence