HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Aminobenzothiazole → 2-(2-Trifluoromethylphenylamino)-1H-benzoimidazole-5-carboxylic acid benzothiazol-6-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Aminobenzothiazole | HCID 68288 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 178524173 | HCID 178524173 | — |
| Product | 2-(2-Trifluoromethylphenylamino)-1H-benzoimidazole-5-carboxylic acid benzothiazol-6-ylamide | HCID 178521789 | — |
Reaction Steps
The carboxylic acid obtained as above (0.25 mmol) was coupled with 6-aminobenzothiazole (0.25 mmol) using HBTU employing general procedure D. The product, 2-(2-Trifluoromethylphenylamino)-1H-benzoimidazole-5-carboxylic acid benzothiazol-6-ylamide, was obtained as a light brown solid after purification by silica gel chromatography using DCM/methanol as eluent. MS: m/z 454 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820821B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-2c3f6802f84644fdb5b8f649207960f4 |
| Source note | uspto-grants-2010_10 |