反应详情

Into a reactor were fed 2.4 g (12.2 m moles) of 1-(4,6-dimethoxypyrimidine-2-yl)-2-propanone, 1.7 g (9.98 m moles) of 2-ethylphenylhydrazine hydrochloride, 1.4 g (10.2 m moles) of zinc chloride and 10 ml of toluene, followed by refluxing for 2 hours with heating. After the completion of the reaction, the reaction mixture was cooled to room temperature. Thereto were added water and ethyl acetate and phase separation was made. The ethyl acetate layer was concentrated. The concentrate was subjected to silica gel column chromatography separation (developing solvent: n-hexane/ethyl acetate) to obtain 2.38 g (8.01 m moles) of 3-(4,6-dimethoxypyrimidine-2-yl)-2-methyl-7-ethylindole.

1. customInto a reactor were fed
2. temperatureby refluxing for 2 hours
3. temperaturewith heating
4. customAfter the completion of the reaction
5. additionThereto were added
6. customwater and ethyl acetate and phase separation
7. concentrationThe ethyl acetate layer was concentrated
8. customThe concentrate was subjected to silica gel column chromatography separation (developing solvent: n-hexane/ethyl acetate)