Ammonium Chloride → HCID 178491911, compound

HRID 1163455Notes

Reaction equation

HRID 1163455 reaction equation
[Cl:1][C:2]1([O:22][CH3:23])[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([C:10]([CH2:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])=[O:11])[NH:3]1.[BH4-].[Na+].[Cl-].[NH4+]>C(O)C>[Cl:1][C:2]1([O:22][CH3:23])[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([CH:10]([OH:11])[CH2:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:14])[NH:3]1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 178491910HCID 178491910, compound

Product 1

HCID 178491911HCID 178491911, compoundYield 68.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a reactor were placed 1.00 g (3.0 m moles) of 4-chloro-2-(4,6-dimethoxypyrimidine-2-ylcarbonyl)acetanilide and 20 ml of ethanol. The reactor contents were cooled to 5° C. or less. Thereto was added 0.25 g (6.6 m moles) of sodium borohydride. The mixture was stirred at the same temperature for 1 hour. Then, the temperature was increased to room temperature. After the completion of the reaction, an aqueous ammonium chloride solution was added and the mixture was extracted with ethyl acetate. The organic layer was concentrated. The concentrate was purified by silica gel column chromatography (n-hexane/ethyl acetate=1/1) to obtain 0.69 g (2.0 m moles) of 4-chloro-2-(4,6-dimethoxypyrimidine-2-ylhydroxymethyl) acetanilide. Yield: 68%

Workup

  1. customIn a reactor were placed
  2. temperatureThe reactor contents were cooled to 5° C. or less
  3. customAfter the completion of the reaction
  4. extractionthe mixture was extracted with ethyl acetate
  5. concentrationThe organic layer was concentrated
  6. customThe concentrate was purified by silica gel column chromatography (n-hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-ac70a9f0ad0048419e179398a5c08430
Source dataset
uspto-grants-2010_10
Patent number
US07820861B2

Reaction notes

Loading…