Hydrochloric Acid → HCID 57747234, compound

Participants

Reaction Steps

A mixture of 19.4 g (125 mmol) of 4-hydroxy-3-methoxy-benzaldehyde, 1.88 g (12.5 mmol) of sodium iodide and 34.5 g (250 mmol) of potassium carbonate in 1000 ml of ethyl acetate is stirred for 30 minutes. Then 43.6 g (125 mmol) of 2-bromo-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone is added and stirring at room temperature is continued for 16 hours. Then the mixture is acidified with 2N HCl and extracted with ethyl acetate. The combined extracts are washed with water, dried and evaporated. Crystallization of the crude product from dichloro-methane/hexane yields 36.85 g of compound 101, m.p. 99-100° C.

Provenance & Evidence