Potassium Hydroxide → HCID 86631894, compound

Participants

Reaction Steps

6.54 g (20 mmol) of 2-bromo-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone and 1.98 g (30 mmol) of potassium hydroxide are dissolved in 150 ml of acetonitrile and stirred under inert atmosphere at room temperature for 30 minutes. Then 5.27 g (20 mmol) of 2-benzotriazol-2-yl-4-methyl-phenolate is added in portions. Stirring at room temperature is continued for additional 3 hours. After adjusting the pH to 6-7 the mixture is extracted with ethyl acetate. The collected organic phases are washed with water, dried and evaporated. Crystallization of the crude product from methanol gives 6.85 g of compound 106, m.p. 155-157° C.

Provenance & Evidence