Hydrochloric Acid → HCID 67425364, compound

Participants

Reaction Steps

A mixture of 3.03 g (15 mmol) of potassium 1,3-dioxo-1,3-dihydro-isoindol-2-olate [prepared according to P. Consonni, D Favara, A. Omodei-Salé, G. Bartolini, A. Ricci, J. Chem. Soc., Perkin Trans. 2, 1983, 967-973], 3.82 g (15 mmol) of 2-chloro-1-(4-hydroxy-3,5-di-iso-propyl-phenyl)-ethanone, 2.3 ml of triethylamine and 100 ml of dimethylformamide is stirred at room temperature and under nitrogen atmosphere for 1.5 hours. Then the mixture is poured onto 500 ml of water containing 9 ml of 2N HCl and is extracted with ethyl acetate. The collected organic phases are washed with water, dried and evaporated. The resulting crude product is recrystallized from ethyl acetate and hexane to give 2.52 g of compound 114, m.p. 136-139°.

Provenance & Evidence