3,4-Dichloroaniline → (2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amine

HRID 1163503Notes

Reaction equation

HRID 1163503 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:15]=[CH:16][C:17]=1[Cl:18])[NH2:14]>>[Cl:1][C:2]1[N:7]=[C:6]([NH:14][C:13]2[CH:15]=[CH:16][C:17]([Cl:18])=[C:11]([Cl:10])[CH:12]=2)[C:5]([F:9])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 72573,4-DichloroanilineHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 22060411(2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amine

Procedure

In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 3,4-dichloroaniline gave 2-chloro-N4-(3,4-dichlorophenyl)-5-fluoro-4-pyrimidineamine. LCMS: purity: 95%; MS (m/e): 294 (M+2H).

Workup

  1. customIn like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine

Sources & evidence

ORD record
ord-5c601304ea1c47468d1d076afbdeb88c
Source dataset
uspto-grants-2010_10
Patent number
US07820819B2

Reaction notes

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