3-Aminophenol → HCID 22060617, compound

HRID 1163780Notes

Reaction equation

HRID 1163780 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[C:10]1[N:15]=[C:14]([NH:16][C:17]2[CH:22]=[C:21]3[O:23][CH2:24][O:25][C:18]=2[C:19]([F:27])=[C:20]3[F:26])[C:13]([F:28])=[CH:12][N:11]=1>>[F:27][C:19]1[C:18]2[O:25][CH2:24][O:23][C:21]([C:20]=1[F:26])=[CH:22][C:17]=2[NH:16][C:14]1[C:13]([F:28])=[CH:12][N:11]=[C:10]([NH:5][C:4]2[CH:6]=[CH:7][CH:8]=[C:2]([OH:1])[CH:3]=2)[N:15]=1

Participants

3

Reactant 2

HCID 115683-AminophenolHCID 220602142-chloro-N4-(3,4-difluoromethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine

Product 1

HCID 22060617HCID 22060617, compound

Procedure

In like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine, the reaction of 3-hydroxyaniline with 2-chloro-N4-(3,4-difluoromethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine gave N4-(3,4-difluoromethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine. LCMS: purity: 85%; MS (m/e): 377 (MH+).

Workup

  1. customIn like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine

Sources & evidence

ORD record
ord-bea4bf615a2c45dfb9212f45a1b6ecdb
Source dataset
uspto-grants-2010_10
Patent number
US07820819B2

Reaction notes

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