2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → HCID 20438532, compound

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Reaction Steps

16.8 g. of 2-amino-pyrroline are dissolved in 140 ml. of ethanol and the solution is cooled to -5° C. and under stirring added dropwise to a solution of 33.8 g. of ethyl ethoxy-methylene-cyanoacetate in 250 ml. of ethanol. The reaction mixture is allowed to warm up to room temperature, and boiled for an hour. The reaction is then allowed to crystallize under cooling below 0° C. The precipitated crystals are filtered and thus 13.7 g. (42.5%) of 3-cyano-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine are obtained, melting at 119°-121° C. after recrystallization from ethanol.

Provenance & Evidence