Methyl iodide → HCID 20438525, compound

HRID 1163868Notes

Reaction equation

HRID 1163868 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=[C:3]1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH3:16][I:17]>CC(C)=O>[I-:17].[CH2:14]([O:13][C:11]([C:3]1[C:2](=[O:1])[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N+:5]([CH3:16])[CH:4]=1)=[O:12])[CH3:15]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 12778914HCID 12778914, compound

Product 1

HCID 20438525HCID 20438525, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2.08 g. of ethyl 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-3-carboxylate are dissolved in 5 ml. of acetone and to the solution 2.5 ml. of methyl iodide are added. After 24 hours the precipitated crystals are filtered and washed with acetone. 2.61 g. (74%) of 3-ethoxycarbonyl-1-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidinium iodide are obtained melting under decomposition at 212° C.

Workup

  1. filtrationAfter 24 hours the precipitated crystals are filtered
  2. washwashed with acetone

Sources & evidence

ORD record
ord-d0964780df1c4d1fb6d3d8ced7b47f8f
Source dataset
uspto-grants-1983_01
Patent number
US04367229

Reaction notes

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