Hydrochloric Acid → HCID 20513280, compound

Participants

Reaction Steps

A mixture of N-methyl-N-(1-benzylpiperid-4-yl)-2-methoxy-4-acetamido-5-chlorbenzamide (12.9 g; 0.03 moles), prepared as described in Example 1, concentrated hydrochloric acid (10 ml) and water (30 ml) was boiled under reflux for 2 hours. The solution was concentrated in vacuo and the residue recrystallized from ethanol. The N-methyl-N-(1-benzylpiperid-4-yl)-2-methoxy-4-amino-5-chloro-benzamide hydrochloride (10.8 g) was obtained, m.p. 259°-260° C. (dec.)

Provenance & Evidence