Phosgene → HCID 20513329, compound

Participants

Reaction Steps

A moderate stream of phosgene is passed into a solution of 5.8 g. 2,3-diamino-1-(2-hydroxy-3-tert.-butylaminopropoxy)-5-methylbenzene trihydrochloride in 150 ml. water for about 30 minutes. After flushing with nitrogen, the reaction mixture is evaporated to dryness and the residue crystallised from ethanol to give 3.04 g. (61% of theory) 4-(2-hydroxy-3-tert.-butylaminopropoxy)-6-methyl-2-benzimidazolinone hydrochloride; m.p. 280°-281° C.

Provenance & Evidence