Phosgene → HCID 12926635, compound

HRID 1163896Notes

Reaction equation

HRID 1163896 reaction equation
Cl.Cl.Cl.NC1C(N)=C(C)C=CC=1OCC(O)CNC(C)(C)C.C(Cl)(Cl)=O.Cl.[OH:28][CH:29]([CH2:43][NH:44][C:45]([CH3:48])([CH3:47])[CH3:46])[CH2:30][O:31][C:32]1[C:40]2[NH:39][C:38](=[O:41])[NH:37][C:36]=2[C:35]([CH3:42])=[CH:34][CH:33]=1>O>[OH:28][CH:29]([CH2:43][NH:44][C:45]([CH3:48])([CH3:47])[CH3:46])[CH2:30][O:31][C:32]1[C:40]2[NH:39][C:38](=[O:41])[NH:37][C:36]=2[C:35]([CH3:42])=[CH:34][CH:33]=1

Participants

5

Reactant 3

HCID 6371PhosgeneHCID 20513301HCID 20513301, compoundHCID 20513307HCID 20513307, compound

Product 1

HCID 12926635HCID 12926635, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.0 g. 2,3-Diamino-1-(2-hydroxy-3-tert.-butylaminopropoxy)-4-methylbenzene trihydrochloride are dissolved in 220 ml. water. Phosgene is passed into the solution and the precipitated crystals are filtered off with suction. After recrystallisation thereof from ethanol, with the addition of active charcoal, there are obtained 3.55 g. (54% of theory) 4-(2-hydroxy-3-tert.-butylaminopropoxy)-7-methyl-2-benzimidazolinone hydrochloride, the decomposition point of which is 312° C.

Workup

  1. filtrationthe precipitated crystals are filtered off with suction
  2. customAfter recrystallisation
  3. additionfrom ethanol, with the addition of active charcoal, there
  4. customare obtained 3.55 g
  5. customis 312° C.

Sources & evidence

ORD record
ord-2ebbdd61bda64e79a517c24bab8e8667
Source dataset
uspto-grants-1983_01
Patent number
US04367235

Reaction notes

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