Methanol → 2-Chloro-6-methoxybenzaldehyde

2-Chloro-6-fluorobenzaldehyde (51.5 g., 0.030 mole) was taken into 500 ml. of methanol. Sodium hydroxide (14.4 g., 0.35 mole) was added and the stirred reaction mixture heated to reflux for 3 hours. The mixture was cooled to room temperature, and the volume reduced to 200 ml. by distillation in vacuo. Water (400 ml.) and methylene chloride (200 ml.) were added and the two phase system equilibrated. The organic phase was separated and the aqueous phase extracted with two additional 100 ml. portions of methylene chloride. The combined organic layers were dried over anhydrous sodium sulfate, filtered and the methylene chloride removed by distillation at atmospheric pressure with displacement by hexane (450 ml.) to a final volume of 300 ml. The product layer, initially present as an oil, began to crystallize at 45° C. The mixture was cooled to room temperature, granulated for 16 hours, and filtered to yield 2-chloro-6-methoxybenzaldehyde [35.6 g., 64.2%; Rf 0.2 (CHCl3 )].

1. customthe stirred reaction mixture
2. temperatureheated
3. temperatureto reflux for 3 hours
4. distillationby distillation in vacuo
5. additionWater (400 ml.) and methylene chloride (200 ml.) were added
6. customThe organic phase was separated
7. extractionthe aqueous phase extracted with two additional 100 ml
8. dry with materialThe combined organic layers were dried over anhydrous sodium sulfate
9. filtrationfiltered
10. customthe methylene chloride removed by distillation at atmospheric pressure with displacement by hexane (450 ml.) to a final volume of 300 ml
11. customto crystallize at 45° C
12. temperatureThe mixture was cooled to room temperature
13. filtrationfiltered

ORD record

ord-07092170275f4f3f938112a6090b746c

Source dataset

uspto-grants-1983_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04367234